VISTA® Advanced Magna Relief Formula

Getting enough protein, fats, and other macronutrients is vital for health, but so is obtaining an adequate supply of minerals— especially magnesium. If you’re not meeting your needs for this micronutrient, then you’re missing out. Magnesium is the 4th most common mineral in the human body and supports our bodies down to the cellular level—most notably by acting as a cofactor. A cofactor is a substance that allows enzymes to function properly. Enzymes, in turn, are responsible for igniting or speeding up biochemical reactions in our bodies. Approximately 300 enzymes rely on magnesium, including those involved in using and synthesizing ATP (the molecule that stores and releases energy) and those that create and repair DNA (gene maintenance). In addition, optimal levels of magnesium are required for cell growth and differentiation (the process by which young cells mature to take on specialized forms—e.g., brain cells, heart cells, etc.). Magnesium is crucial to the complex reactions that keep us alive while also supporting the healthy functioning of muscles, the circulatory system, and the brain, and regulating various neurochemical pathways, including those involved in sleep and mood.*

Magnesium for multidimensional relief

Muscular Relief*
In athletic circles, magnesium is renowned for supporting post-workout muscle recovery.* True to its reputation, the body uses magnesium to stimulate glucose flow to the muscles and aids in the clearance of lactate^M—the main culprit responsible for muscle pain and fatigue. Following a muscle contraction, magnesium induces muscle relaxation by blocking calcium from entering cells. Consequently, when magnesium levels are low, things can get a bit tense! People may experience sudden muscle spasms, sharp leg and foot cramps, and back and shoulder pain due to tightness^M.

Mental Relief and Brain Health*
Caring for yourself mentally is just as important as looking after yourself physically. Chronic stress, depression, and anxiety affect an ever-growing number of people across various ages and demographics. The dynamics of modern life—such as working overtime and sitting at a desk for long periods, sleeping too little, spending too much time on social media and screens, and having fewer social interactions—have undoubtedly contributed to this downward trend in well-being. If the problems you are experiencing interfere with your daily life and stop you from feeling good about yourself, then it is advisable to seek help from a mental health professional. In addition, as the population ages, more people will eventually struggle with neurogenerative diseases—i.e., the gradual and progressive loss of neural cells, one example being Alzheimer’s. There are over 600 different types of these diseases, and currently, it’s estimated that over 50 million Americans are affected yearly^L.

Many variables contribute to neurological functioning, and scientists have been striving to discover exactly how nutrition factors into this equation. Recent scientific investigations have uncovered significant relationships between magnesium levels and various aspects of subjective well-being and brain health writ large.

On a general level, magnesium supports healthy nerve transmission. Glutamate—an excitatory neurotransmitter—works by stimulating the NMDA receptors on brain cells (neurons). Importantly, magnesium is a blocker of NMDA receptors. Therefore, magnesium helps to buffer against excessive neuronal excitation, which if left unchecked, can cause the death of brain cells (excitotoxicity)^N.*

Magnesium is found in several enzymes, hormones, and neurotransmitters—accordingly, it’s not surprising that researchers have observed a link between low magnesium levels and neurological disorders, such as depression, anxiety, migraine, chronic pain, fibromyalgia^C, and more generally, nervous hyperexcitability^O. Magnesium supplementation has been linked to improvements in symptoms of major depression, as well as reduced rates of depression in adults under 65^K.* Magnesium may guard against depression through its neuroprotective effects (preventing damage to brain structures by buffering against cell death)^C and by fighting the markers of inflammation^K. In general, deficiencies in magnesium contributes to systemic low-grade inflammation, which is a common denominator in many diseases and neurodegenerative disorders^S.* Indeed, unbalanced magnesium levels have been correlated with neurodegenerative diseases, such as Parkinson’s disease, Alzheimer’s disease, and demyelination of neurons (myelin is the tissue found on some neurons that helps speed up the transmission of signals).

Magnesium and the Sleep Cycle
Most people do not get enough sleep on a nightly basis. Sleep disorders affect a staggering 50 – 70 million Americans, and many people at some point will experience acute insomnia that can last for a few days or a couple of weeks. Our natural circadian rhythms are routinely thrown out of balance for various reasons, including but not limited to work-related issues (long, irregular, or night shifts), excessive exposure to artificial lighting past sundown paired with a lack of exposure to natural sunlight, too much screentime, caffeine consumption near bedtime, a poor-quality sleeping environment (uncomfortable bed, suboptimal room temperature and lighting, noise, etc.). Not only does a lack of sleep make it difficult for you to function the following day and increases the risk of being in an accident, but it’s also correlated with an increase in all-cause mortality, heart disease, and the risk of obesity. Sleep is when our bodies undergo repairs, restore depleted cellular components, and rid cells of waste. Our brains especially need sleep since it allows enzymes to repair damage caused by free radicals (oxidative stress), flush out toxins, and for neurons to rest. Sleep can also be disrupted by stress, rumination, anxiety, and depression. This pattern can also work in the opposite direction—a deficiency of sleep can cause or worsen mental health issues.

Most people are unaware of how stressed they are, or similarly, when people are trying to sleep, they may not notice how frequently negative and repetitive thoughts populate their consciousness. When a person is chronically stressed, their body is releasing hormones and neurotransmitters that generates a constant state of fight or flight. When you’re stressed, your body thinks it needs to take action, which means falling asleep is not a goal. Magnesium is essential for activating mechanisms in the brain that aid in quelling this response. Magnesium helps regulate melatonin production (the hormone that influences sleep) and stimulates the release of GABA^O, a neurotransmitter that inhibits neuronal activity. For individuals who struggle with insomnia or restless legs syndrome, magnesium may help promote the relaxation they need.*

Magnesium and Cardiovascular Health*
Poor cardiovascular health is rampant in the United States. Nearly 1 out of 5 deaths are due to cardiovascular diseaseR. In 2020, 697,000 people died from heart disease, which shockingly translates into one person dying every 34 secondsR! High blood pressure (hypertension) is also frighteningly pervasive in the United States, afflicting nearly 50% of adults. Hypertension is a strong predictor of atherosclerosis, which ultimately can lead to cardiovascular disease.

Your body relies on magnesium to regulate the intricate biochemical and cellular processes needed to keep your heart functioning and beating rhythmically. When magnesium gets too low, arrhythmias and heart palpitations can occur. Additionally, hypertension is more likely to occur when your electrolytes are out of balance—specifically when sodium (table salt) consumption is high and intake of other minerals, such as potassium, calcium, and magnesium, is low^Q. Magnesium also blocks calcium from entering cells, which has the effect of relaxing blood vessels and lowering blood pressure.*

A growing body of scientific literature suggests that magnesium has an inverse association with cardiovascular and metabolic diseases. That is, studies have found that higher circulating levels of magnesium were related to lower levels of ischemic heart disease and coronary heart disease^P. A recent meta-analysis on the effects of dietary intake of magnesium found that greater magnesium consumption was associated with a reduced risk of type 2 diabetes, stroke, heart failure, and all-cause mortality.^R Dietary magnesium may also be linked to improvements in a person’s lipid profile—LDL (“bad”) cholesterol is lower while HDL (“good”) cholesterol is higher^P. Experimental and observational studies have shown that higher dietary magnesium was linked with improved glucose and insulin metabolism^P, and relatedly, supplementation may also have a beneficial role by improving glucose markers in people with diabetes as well as insulin-sensitivity parameters in those at high risk of diabetes^F.*

Magnesium: Deficiencies and Dietary Needs
Everyone knows how important diet is to health—good nutrition is foundational to living your best life. Empirical evidence also suggests diet underpins psychological health and plays a significant role in stabilizing mood and promoting well-being. Magnesium is required to keep you physically and mentally balanced—but how do you if you’re getting enough of this essential mineral?

Magnesium is present in many whole foods, such as green vegetables (e.g., spinach, Swiss chard, okra, broccoli), legumes (e.g., peanuts), nuts (e.g., almonds and cashews), seeds (e.g., pumpkin, chia), and fish (e.g., salmon, mackerel). While it is possible to obtain magnesium from a balanced diet, as many as two-thirds of people in Western countries, fail to meet their magnesium needs with diet alone^D. This is in part due to an increase in the overall consumption of highly processed foods (e.g., white flour and sugar), as well as other factors, such as the diminished levels of magnesium in some nonorganic foods, certain cooking techniques (e.g., boiling), and reduced gastrointestinal absorption (due to vitamin D deficiency and medications). Notably, individuals that are more likely to be deficient in magnesium include older men, teens, and people with gastrointestinal issues, kidney problems, and type 2 diabetes. Hypo-magnesemia, an electrolyte disturbance characterized by lower-than-normal magnesium levels in the blood, is fairly common. Somewhere between 2.5 to 15% of the general population are hypomagnesemic. Relatedly, as many as 10 to 20% of hospitalized patients are deficient in magnesium, and up to 65% of patients in intensive care units are hypomagnesemic^B.

Magnesium Supplementation
Given that magnesium supports hundreds of biochemical reactions in your body, it is important to meet your daily needs for this critical mineral. When the diet fails, supplementing can help fill the nutritional gap.

Magnesium is an element that readily forms ionic bonds with other compounds, and thus it comes in many forms (salts). Each form of magnesium has its own distinguishing properties. As such, it is important to know what you’re taking and how it affects your body—certain salts of magnesium are not as bioavailable as others, and additionally, some can have undesirable side effects (i.e., gastrointestinal issues and laxative effects). In addition, not just one form of magnesium is best. Just as your body requires a rich supply of diverse nutrients, different parts of your body have different nutritional needs.

VISTA Magna Relief Formula is a cutting-edge, proprietary blend of 7 forms of Magnesium designed to support critical functions in the human body including brain health, heart health, energy production, muscle movements, and many more.* We adhere to strict safety standards to ensure you are getting exactly what’s stated on the label. We pride ourselves on purity—no secret additives and absolutely no surprises. Our formula provides 500 mg of the highest-grade Elemental Magnesium in the most bio-available forms of Magnesium, each providing unique benefits.

• Magnesium Glycinate: Magnesium glycinate is formed by combining elemental magnesium with the amino acid glycine. This form of magnesium is highly bioavailable. Magnesium glycinate supports inflammatory conditions like heart health and diabetes.^A It is also commonly used for its calming effects to treat anxiety, depression, and insomnia.^B*
• Magnesium Citrate: Magnesium citrate is a form of magnesium that’s bound with citric acid and acts as a calming agent to help relieve symptoms associated with depression and anxiety.^C Due to its natural laxative effect, it’s also sometimes used at higher doses to treat constipation.*
• Magnesium Aspartate: Proper intake of magnesium through magnesium aspartate can help lower the risk of type 2 diabetes^F, lower the frequency of migrainesG and treatment of mild-to-moderate form of depression.^C*
• Magnesium Malate: Magnesium malate is easily absorbed and may have less of a laxative effect than other forms. It’s can support chronic conditions like fibromyalgia and chronic fatigue syndrome.^H*
• Magnesium Orotate: Magnesium orotate may bolster heart health by improving energy production in heart and blood vessel tissue.^I,J*
• Magnesium Gluconate: Magnesium gluconate is a chelated magnesium salt bonded to gluconic acid, improving its ability to cross the intestinal barrier for higher absorption. It can enhance sleep quality and mood disorders.^C*
• Magnesium Beta-hydroxybutyrate (BHB): Magnesium BHB help ketosis, cognitive function, brain & nerve function, as well as inflammation and muscle function.^B,C It is known to help boost athletic endurance.*

References:

1. Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review https://pubmed.ncbi.nlm.nih.gov/28337245/
2. Magnesium in the Central Nervous System https://www.ncbi.nlm.nih.gov/books/NBK507271/
3. The Role of Magnesium in Neurological Disorders https://pubmed.ncbi.nlm.nih.gov/29882776/
4. The Importance of Magnesium in Clinical Healthcare https://pubmed.ncbi.nlm.nih.gov/29093983/
5. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0180067
6. Effect of magnesium supplementation on glucose metabolism in people with or at risk of diabetes: a systematic review and meta-analysis of double-blind randomized controlled trials https://pubmed.ncbi.nlm.nih.gov/27530471/
7. Effects of Intravenous and Oral Magnesium on Reducing Migraine: A Meta-analysis of Randomized Controlled Trials https://pubmed.ncbi.nlm.nih.gov/26752497/
8. Magnesium and malic acid supplement for fibromyalgia https://pubmed.ncbi.nlm.nih.gov/31150373/
9. Magnesium orotate--experimental and clinical evidence https://pubmed.ncbi.nlm.nih.gov/16366126/
10. Magnesium orotate in severe congestive heart failure (MACH) https://pubmed.ncbi.nlm.nih.gov/19367681/
11. Magnesium intake and depression in adults https://pubmed.ncbi.nlm.nih.gov/25748766/
12. Neurodegenerative Diseases: An Overview of Environmental Risk Factors https://ehp.niehs.nih.gov/doi/10.1289/ehp.7567
13. Magnesium Enhances Exercise Performance via Increasing Glucose Availability in the Blood, Muscle, and Brain during Exercise https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896381/
14. Magnesium acts as a second messenger in the regulation of NMDA receptor mediated CREB signaling in neurons https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8202957/
15. Magnesium in neuroses and neuroticism https://www.ncbi.nlm.nih.gov/books/NBK507254/
16. Dietary Magnesium and Cardiovascular Disease: A Review with Emphasis in Epidemiological Studies https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852744/
17. Dietary magnesium intake and the risk of cardiovascular disease, type 2 diabetes, and all-cause mortality: a dose–response meta-analysis of prospective cohort studies https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143460/
18. CDC 2020 Heart Disease Facts https://www.cdc.gov/heartdisease/facts.htm
19. Magnesium and the Brain: A Focus on Neuroinflammation and Neurodegeneration https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820677/