VISTA® Advanced D-Mannose Formula

• HEALTHY URINARY TRACT*
• CLEANSES THE BLADDER*

Urinary Tract Health

The urinary tract and associated organs are akin to the body's natural plumbing system. It functions to filter out waste and maintain a delicate balance of fluids and electrolytes. Just like any other bodily system, it requires proper care to keep running smoothly Staying hydrated and, furthermore, being attentive to any irregularities or discomfort is crucial, as these can indicate underlying infections.

UTI Symptoms

The symptoms of UTIs can vary widely, both in the number of symptoms experienced and their severity, differing from person to person. Some people may not have obvious symptoms in spite of the presence of an infection¹. In can also depend on whether a person has an upper or lower UTI. Upper UTIs affect the kidneys and the ureters (the tubes that connect the kidneys to the bladder) while lower UTIs affect the urethra and the bladder. Notably, lower UTIs are significantly more common.

Some of the most common symptoms of lower UTIs include:

• A strong, persistent urge to urinate
• Frequent urination but only passing small amounts of urine
• Signs of blood in the urine—it may appear red or bright pink
• Cloudy or strong-smelling urine
• Pelvic pain, in women

Upper UTIs are often accompanied by pain in the back or side (kidney pain) and/or a fever and flu-like symptoms (e.g., chills, nausea, vomiting)

UTI Prevalence

Across the globe, UTIs are estimated to afflict over 150 million people each year¹. In the United States, a self-report study found that nearly 11% of adult women surveyed reported a UTI in the prior 12 months. The authors estimated that approximately 1/3 of women will have a clinically diagnosed UTI by age 24³ and other sources suggest the lifetime incidence in women is approximately 50-60%⁴.

While UTIs are especially common in women due to a shorter urethra, men are not immune to these infections. Approximately 3 out of 25 men will in their lifetime experience the symptoms of a UTI⁵.

UTIs begin when bacteria—most commonly E. coli—enter the urethra and cling to the lining using adhesin proteins. The bacteria build up a glue-like biofilm⁶ and, if not flushed out by urination, can migrate to the bladder and wreak havoc.

Antibiotics & Recurrence

People seeking treatment for a UTI are typically prescribed antibiotics. However, reinfection is common, with about 20 to 30% of women experiencing a repeat infection within 4 to 6 months⁷. This cycle is problematic not only because UTIs are uncomfortable, but also because it contributes to the growing issue of antibiotic resistance⁸. In addition, some UTIs may be caused by a fungal infection.¹⁰

Cranberry Juice and Extract

UTIs can sometimes resolve on their own, but not in all cases, thus it is best to seek advice from a professional healthcare provider. Discomfort often prompts people to seek out natural remedies like cranberry juice. Cranberries contain proanthocyanidins which can interfere with bacteria’s ability to adhere to the walls of the urinary tract. According to the fifth update of a Cochrane meta-analysis, cranberry products may reduce the risk of symptomatic, culture‐verified UTIs in women with recurrent UTIs⁹. While drinking cranberry juice is considered safe and may offer some benefits, these drinks are often high in sugar, which can make them an unappealing option. VISTA® Asvanced D-Mannose Formula packs the punch of the cranberry’s proanthocyanidins without the downside of spiking insulin levels.

VISTA® Advanced D-Mannose Formula

Given that bacteria, such as E. coli, adheres to the inside of the urethra and bladder using sticky biofilms, a logical approach to preventing and treating UTIs is to target this mechanism. Staying hydrated helps since regular urination can prevent bacteria from hunkering down, however, infections may still occur.

Fortunately, VISTA® Advanced’s high-quality D-mannose can help. In a randomized clinical study involving 308 women with a history of recurrent UTIs, D-mannose supplementation demonstrated efficacy in preventing future infections¹¹.* Additionally, a recent literature review concluded that D-mannose is a promising alternative to antibiotics, showing comparable effectiveness in relieving symptoms and achieving cure rates¹⁰.*

D-mannose is a naturally occurring simple sugar that your body can use to cleanse the urinary tract and support a healthy bladder lining.* Unlike glucose, fructose or sucrose (table sugar), D-mannose is not metabolized nor is it stored in the liver or fat cells¹⁰. Instead, it is quickly excreted in the urine about an hour after ingestion¹⁰. Accordingly, VISTA® Advanced D-Mannose Formula will not impact insulin levels or interfere with healthy blood sugar regulation. Best of all, it will not contribute to the very real problem of antibacterial resistance.

VISTA® Advanced D-Mannose Formula’s unique formulation combines the benefits of a naturally occurring molecule with powerful cranberry proanthocyanidins to cleanse the bladder supporting a healthy urinary environment.*

References:

1. Rajanbir Kaur, Rajinder Kaur, Symptoms, risk factors, diagnosis and treatment of urinary tract infections, Postgraduate Medical Journal, Volume 97, Issue 1154, December 2021, Pages 803–812, https://doi.org/10.1136/postgradmedj-2020-139090
2. Öztürk R., Murt A. Epidemiology of urological infections: A global burden. World J. Urol. 2020;38:2669–2679. doi: 10.1007/s00345-019-03071-4.
3. Foxman B, Barlow R, D'Arcy H, Gillespie B, Sobel JD. Urinary tract infection: self-reported incidence and associated costs. Ann Epidemiol. 2000 Nov;10(8):509-15. doi: 10.1016/s1047-2797(00)00072-7. PMID: 11118930.
4. Medina M, Castillo-Pino E. An introduction to the epidemiology and burden of urinary tract infections. Ther Adv Urol. 2019 May 2;11:1756287219832172. doi: 10.1177/1756287219832172. PMID: 31105774; PMCID: PMC6502976.
5. Understanding UTIs across the Lifespan - Urology Care Foundation. (n.d.). https://www.urologyhealth.org/healthy-living/urologyhealth-extra/magazine-archives/summer-2016/understanding-utis-across-the-lifespan
6. Wagenlehner F, Lorenz H, Ewald O, Gerke P. Why d-Mannose May Be as Efficient as Antibiotics in the Treatment of Acute Uncomplicated Lower Urinary Tract Infections-Preliminary Considerations and Conclusions from a Non-Interventional Study. Antibiotics (Basel). 2022 Feb 25;11(3):314. doi: 10.3390/antibiotics11030314. PMID: 35326777; PMCID: PMC8944421.
7. Foxman B., Gillespie B., Koopman J., Zhang L., Palin K., Tallman P., Marsh J.V., Spear S., Sobel J.D., Marty M.J., et al. Risk factors for second urinary tract infection among college women. Am. J. Epidemiol. 2000;151:1194–1205. doi: 10.1093/oxfordjournals.aje.a010170.
8. Negus M., Phillips C., Hindley R. Recurrent urinary tract infections: A critical review of the currently available treatment options. Obstet. Gynaecol. 2020;22:115–121. doi: 10.1111/tog.12644.
9. Williams, G., Stothart, C. I., Hahn, D., Stephens, J. H., Craig, J. C., & Hodson, E. M. (2023). Cranberries for preventing urinary tract infections. Cochrane Library, 2023(11). https://doi.org/10.1002/14651858.cd001321.pub7
10. Parazzini, F., Ricci, E., Fedele, F., Chiaffarino, F., Esposito, G., & Cipriani, S. (2022). Systematic review of the effect of D mannose with or without other drugs in the treatment of symptoms of urinary tract infections/cystitis (Review). Biomedical Reports, 17, 69. https://doi.org/10.3892/br.2022.1552
11. Kranjčec, B., Papeš, D. & Altarac, S. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J Urol 32, 79–84 (2014). https://doi.org/10.1007/s00345-013-1091-6